SCO1

SCO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WP0, 2GGT, 2GQK, 2GQL, 2GQM, 2GT5, 2GT6, 2GVP, 2HRF, 2HRN
Identifiers
Aliases	SCO1, SCOD1, SCO1 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, SCO cytochrome c oxidase assembly protein 1, synthesis of cytochrome C oxidase 1, MC4DN4
External IDs	OMIM: 603644; MGI: 106362; HomoloGene: 3374; GeneCards: SCO1; OMA:SCO1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	10,698,375 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	66,957,896 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; gonad; ; mucosa of transverse colon; ; cardiac muscle tissue of right atrium; ; mucosa of ileum; ; tibialis anterior muscle; ; Achilles tendon; ; gastrocnemius muscle; ; right lobe of liver; ; right adrenal cortex;
	Top expressed in
	interventricular septum; ; jejunum; ; Paneth cell; ; right kidney; ; duodenum; ; embryo; ; embryo; ; ventricular zone; ; yolk sac; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; copper ion binding; metal ion binding;
Cellular component	myofibril; host cell mitochondrial intermembrane space; mitochondrion; mitochondrial inner membrane; integral component of mitochondrial inner membrane; membrane; integral component of membrane;
Biological process	cellular copper ion homeostasis; generation of precursor metabolites and energy; copper ion transport; respiratory chain complex IV assembly; negative regulation of proteasomal protein catabolic process; mitochondrial cytochrome c oxidase assembly;
	Sources:Amigo / QuickGO
Orthologs
	6341
	52892
	ENSG00000133028
	ENSMUSG00000069844
	O75880
	Q5SUC9
	NM_004589
	NM_001040026
	NP_004580
	NP_001035115
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SCO1 homolog, mitochondrial, also known as SCO1, cytochrome c oxidase assembly protein, is a protein that in humans is encoded by the SCO1 gene. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable, as well as to tissues with high levels of oxidative phosphorylation. The expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase (complex IV) deficiency.