SDHB

SDHB
Identifiers
Aliases	SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN4
External IDs	OMIM: 185470; MGI: 1914930; HomoloGene: 2255; GeneCards: SDHB; OMA:SDHB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,054,032 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,706,504 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; mucosa of transverse colon; ; right ventricle; ; right auricle of heart; ; right lobe of liver; ; vastus lateralis muscle; ; biceps brachii;
	Top expressed in
	right ventricle; ; myocardium of ventricle; ; digastric muscle; ; interventricular septum; ; plantaris muscle; ; sternocleidomastoid muscle; ; cardiac muscles; ; soleus muscle; ; thoracic diaphragm; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquinone binding; iron-sulfur cluster binding; metal ion binding; succinate dehydrogenase (ubiquinone) activity; protein binding; oxidoreductase activity; electron transfer activity; 2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding;
Cellular component	membrane; plasma membrane; nucleoplasm; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); mitochondrial inner membrane; mitochondrion; mitochondrial membranes; respiratory chain complex II;
Biological process	succinate metabolic process; aerobic respiration; tricarboxylic acid cycle; respiratory electron transport chain; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	6390
	67680
	ENSG00000117118
	ENSMUSG00000009863
	P21912
	Q9CQA3
	NM_003000
	NM_023374; NM_001355515
	NP_002991
	NP_075863; NP_001342444
	Wikidata
View/Edit Human	View/Edit Mouse

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene.

The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa.