SIGLEC8

SIGLEC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N7B, 2N7A
Identifiers
Aliases	SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L, sialic acid binding Ig like lectin 8
External IDs	OMIM: 605639; MGI: 2681107; HomoloGene: 50482; GeneCards: SIGLEC8; OMA:SIGLEC8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,458,456 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,008,955 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; spleen; ; lymph node; ; right adrenal cortex; ; left adrenal gland; ; substantia nigra; ; left adrenal cortex; ; internal globus pallidus; ; prefrontal cortex; ; gallbladder;
	Top expressed in
	granulocyte; ; right lung lobe; ; primary oocyte; ; embryo; ; secondary oocyte; ; morula; ; blood; ; zygote; ; bone marrow; ; intestinal villus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; carbohydrate binding;
Cellular component	integral component of membrane; membrane;
Biological process	cell adhesion; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27181
	233186
	ENSG00000105366
	ENSMUSG00000039013
	Q9NYZ4
	Q920G3
	NM_014442; NM_001363548
	NM_001271019; NM_145581
	NP_055257; NP_001350477
	NP_001257948; NP_663556
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene. This gene is located on chromosome 19q13.4, about 330 kb downstream of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone rapid evolution.