Glucose-6-phosphate exchanger SLC37A4

SLC37A4
Identifiers
Aliases	SLC37A4, G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG-19, TRG19, PRO0685, solute carrier family 37 member 4, CDG2W
External IDs	OMIM: 602671; MGI: 1316650; HomoloGene: 37482; GeneCards: SLC37A4; OMA:SLC37A4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,030,906 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,314,265 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; body of pancreas; ; islet of Langerhans; ; renal cortex; ; human kidney; ; mucosa of transverse colon; ; gastrocnemius muscle; ; rectum; ; skeletal muscle tissue;
	Top expressed in
	right kidney; ; vastus lateralis muscle; ; triceps brachii muscle; ; proximal tubule; ; human kidney; ; muscle of thigh; ; extensor digitorum longus muscle; ; left lobe of liver; ; sternocleidomastoid muscle; ; tibialis anterior muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; glucose-6-phosphate transmembrane transporter activity; glucose 6-phosphate:inorganic phosphate antiporter activity; antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	glucose-6-phosphate transport; phosphate ion transmembrane transport; glucose metabolic process; glucose homeostasis; carbohydrate transport; transmembrane transport; gluconeogenesis; transport;
	Sources:Amigo / QuickGO
Orthologs
	2542
	14385
	ENSG00000137700; ENSG00000281500
	ENSMUSG00000032114
	O43826
	n/a
	NM_001467; NM_001164277; NM_001164278; NM_001164279; NM_001164280
NM_001293630; NM_001293631; NM_008063; NM_001357729; NM_001357730;
	NM_001378829; NM_001378830; NM_001378831; NM_001378832; NM_001378833; NM_001378834
	NP_001157749; NP_001157750; NP_001157751; NP_001157752; NP_001458
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.

It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase). This important enzyme complex is located within the membrane of the endoplasmic reticulum, and catalyzes the terminal reactions in both glycogenolysis and gluconeogenesis. The G6Pase complex is most abundant in liver tissue, but also present in kidney cells, small intestine, pancreatic islets and at a lower concentration in the gallbladder. The G6Pase complex is highly involved in the regulation of homeostasis and blood glucose levels. Within this framework of glucose regulation, the translocase components are responsible for transporting the substrates and products across the endoplasmic reticulum membrane, resulting in the release of free glucose into the bloodstream.