SND1

SND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG
Identifiers
Aliases	SND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
External IDs	OMIM: 602181; MGI: 1929266; HomoloGene: 8665; GeneCards: SND1; OMA:SND1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,092,609 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,935,161 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; stromal cell of endometrium; ; islet of Langerhans; ; parotid gland; ; epithelium of colon; ; canal of the cervix; ; left ovary; ; smooth muscle tissue; ; anterior pituitary; ; right ovary;
	Top expressed in
	lacrimal gland; ; parotid gland; ; dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; lip; ; epiblast; ; ventricular zone; ; molar; ; stroma of bone marrow; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transcription coregulator activity; nucleic acid binding; nuclease activity; RNA binding; cadherin binding; endonuclease activity; endoribonuclease activity; hydrolase activity; RISC complex binding;
Cellular component	melanosome; RISC complex; extracellular exosome; mitochondrion; membrane; dense body; cytoplasm; cytosol; nucleus;
Biological process	gene silencing; viral process; regulation of transcription, DNA-templated; osteoblast differentiation; transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; RNA catabolic process; regulation of cell cycle process; miRNA catabolic process; RNA phosphodiester bond hydrolysis, endonucleolytic; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	27044
	56463
	ENSG00000197157
	ENSMUSG00000001424
	Q7KZF4
	Q78PY7
	NM_014390
	NM_019776
	NP_055205
	NP_062750
	Wikidata
View/Edit Human	View/Edit Mouse

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. SND1 is a main component of RISC complex and plays an important role in miRNA function. SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. SND1 is also involved in Autism.