SNX15

SNX15
Identifiers
Aliases	SNX15, HSAF001435, sorting nexin 15
External IDs	OMIM: 605964; MGI: 1916274; HomoloGene: 12294; GeneCards: SNX15; OMA:SNX15 - orthologs
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,178,334 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; prefrontal cortex; ; cerebellar hemisphere; ; monocyte; ; skeletal muscle tissue; ; gastrocnemius muscle; ; popliteal artery; ; right coronary artery; ; Brodmann area 9; ; Amygdala;
	Top expressed in
	blood; ; neural layer of retina; ; superior frontal gyrus; ; fetal liver hematopoietic progenitor cell; ; islet of Langerhans; ; yolk sac; ; lip; ; gastric mucosa; ; primary visual cortex; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol binding; lipid binding;
Cellular component	nucleolus; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; cytoplasm; cytosol;
Biological process	protein transport; signal transduction; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	29907
	69024
	n/a
	ENSMUSG00000024787
	Q9NRS6
	Q91WE1
	NM_147777; NM_013306
	NM_026912
	NP_037438; NP_680086
	NP_081188
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.