SNX3

SNX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YPS, 2MXC
Identifiers
Aliases	SNX3, Grd19, MCOPS8, SDP3, sorting nexin 3
External IDs	OMIM: 605930; MGI: 1860188; HomoloGene: 36144; GeneCards: SNX3; OMA:SNX3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	108,261,246 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	42,411,377 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; middle temporal gyrus; ; visceral pleura; ; parietal pleura; ; endothelial cell; ; right ventricle; ; germinal epithelium; ; parotid gland; ; Epithelium of choroid plexus; ; Brodmann area 23;
	Top expressed in
	lactiferous gland; ; CA3 field; ; pyloric antrum; ; yolk sac; ; fetal liver hematopoietic progenitor cell; ; calvaria; ; plantaris muscle; ; facial motor nucleus; ; perirhinal cortex; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; phosphatidylinositol binding; protein phosphatase binding; lipid binding; phosphatidylinositol phosphate binding;
Cellular component	cytoplasm; cytosol; endosome; early endosome membrane; early phagosome; retromer complex; early endosome; phagocytic vesicle; extracellular exosome; cytoplasmic vesicle; clathrin-coated vesicle; extrinsic component of membrane; endosome membrane;
Biological process	protein to membrane docking; negative regulation of viral entry into host cell; negative regulation of phagocytosis; response to bacterium; negative regulation of protein catabolic process; negative regulation of early endosome to late endosome transport; membrane invagination; regulation of Wnt signaling pathway; intralumenal vesicle formation; negative regulation of protein transport; positive regulation of neuron projection development; protein transport; Wnt signaling pathway; protein deubiquitination; transport;
	Sources:Amigo / QuickGO
Orthologs
	8724
	54198
	ENSG00000112335
	ENSMUSG00000019804
	O60493
	O70492
	NM_152828; NM_001300928; NM_001300929; NM_003795; NM_152827
	NM_017472
	NP_001287857; NP_001287858; NP_003786; NP_690040
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.