SNX4

SNX4
Identifiers
Aliases	SNX4, ATG24B, sorting nexin 4
External IDs	OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	125,520,202 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,120,639 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; Achilles tendon; ; kidney tubule; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; duodenum; ; Epithelium of choroid plexus; ; tendon of biceps brachii;
	Top expressed in
	atrioventricular valve; ; left lung lobe; ; endocardial cushion; ; sciatic nerve; ; granulocyte; ; yolk sac; ; vestibular sensory epithelium; ; ureter; ; primitive streak; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin receptor binding; leptin receptor binding; epidermal growth factor receptor binding; protein binding; phosphatidylinositol binding; transferrin receptor binding; lipid binding;
Cellular component	cytoplasm; extrinsic component of membrane; endosome; early endosome membrane; membrane; plasma membrane; SNARE complex; cytoplasmic dynein complex; protein-containing complex; early endosome;
Biological process	endocytosis; vesicle organization; endocytic recycling; protein transport; positive regulation of histamine secretion by mast cell;
	Sources:Amigo / QuickGO
Orthologs
	8723
	69150
	ENSG00000114520
	ENSMUSG00000022808
	O95219
	Q91YJ2
	NM_003794
	NM_080557
	NP_003785
	NP_542124
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.