SOCS5

SOCS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N34
Identifiers
Aliases	SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs	OMIM: 607094; MGI: 2385459; HomoloGene: 10495; GeneCards: SOCS5; OMA:SOCS5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,780,245 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,445,267 bp
RNA expression pattern
	Top expressed in
	sperm; ; buccal mucosa cell; ; endothelial cell; ; germinal epithelium; ; lactiferous duct; ; parietal pleura; ; saphenous vein; ; cerebellar vermis; ; stromal cell of endometrium; ; Epithelium of choroid plexus;
	Top expressed in
	substantia nigra; ; ventromedial nucleus; ; anterior amygdaloid area; ; nucleus accumbens; ; lateral septal nucleus; ; olfactory tubercle; ; mammillary body; ; globus pallidus; ; lateral hypothalamus; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; protein binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; phosphatidylinositol 3-kinase complex;
Biological process	receptor signaling pathway via JAK-STAT; intracellular signal transduction; epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; cell growth; protein ubiquitination; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of T-helper 2 cell differentiation; positive regulation of T-helper 1 cell differentiation; negative regulation of signal transduction; negative regulation of interleukin-6 production; negative regulation of inflammatory response; cellular response to low-density lipoprotein particle stimulus; negative regulation of monocyte chemotactic protein-1 production; vascular endothelial cell response to fluid shear stress; post-translational protein modification; cytokine-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9655
	56468
	ENSG00000171150
	ENSMUSG00000037104
	O75159
	O54928
	NM_144949; NM_014011
	NM_019654
	NP_054730; NP_659198
	NP_062628
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.