Spondin 1

SPON1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989; MGI: 2385287; HomoloGene: 4453; GeneCards: SPON1; OMA:SPON1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,268,133 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	113,642,605 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; mucosa of sigmoid colon; ; pericardium; ; lower lobe of lung; ; cardia; ; mucosa of urinary bladder; ; external globus pallidus; ; right lung; ; visceral pleura; ; parietal pleura;
	Top expressed in
	epithelium of lens; ; iris; ; ciliary body; ; external carotid artery; ; cervix; ; internal carotid artery; ; retinal pigment epithelium; ; atrium; ; decidua; ; suprachiasmatic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; extracellular matrix structural constituent; LBD domain binding;
Cellular component	extracellular matrix; extracellular region; endoplasmic reticulum lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	cell adhesion; protein O-linked fucosylation; positive regulation of protein processing; positive regulation of protein binding; negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10418
	233744
	ENSG00000262655
	ENSMUSG00000038156
	Q9HCB6
	Q8VCC9
	NM_006108
	NM_145584
	NP_006099
	NP_663559
	Wikidata
View/Edit Human	View/Edit Mouse

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene. It is secreted by cells of the floor plate and may be involved in axon guidance The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.