SPRED3

SPRED3
Identifiers
Aliases	SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs	OMIM: 609293; MGI: 2142186; HomoloGene: 28061; GeneCards: SPRED3; OMA:SPRED3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,399,587 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,869,836 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; lateral nuclear group of thalamus; ; vena cava; ; external globus pallidus; ; right ventricle; ; pars reticulata; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; Pons; ; subthalamic nucleus;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; tail of embryo; ; spermatid; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; ventricular zone; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding;
Cellular component	membrane;
Biological process	multicellular organism development; regulation of signal transduction; negative regulation of peptidyl-threonine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	399473
	101809
	ENSG00000188766
	ENSMUSG00000037239
	Q2MJR0
	Q6P6N5
	NM_001039616; NM_001042522; NM_001394336; NM_001394337; NM_001394338
	NM_182927
	NP_001035987
	NP_891557
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.