Sequestosome 1

SQSTM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9
Identifiers
Aliases	SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV
External IDs	OMIM: 601530; MGI: 107931; HomoloGene: 31202; GeneCards: SQSTM1; OMA:SQSTM1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,838,078 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,101,654 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; stromal cell of endometrium; ; muscle of thigh; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder; ; gastric mucosa; ; Descending thoracic aorta;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; right kidney; ; triceps brachii muscle; ; adrenal gland; ; ventromedial nucleus; ; superior frontal gyrus; ; temporal muscle; ; central gray substance of midbrain; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; receptor tyrosine kinase binding; zinc ion binding; SH2 domain binding; metal ion binding; protein serine/threonine kinase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; identical protein binding; protein kinase binding; protein kinase C binding; ubiquitin binding; enzyme binding; ubiquitin protein ligase binding; ionotropic glutamate receptor binding;
Cellular component	cytoplasm; endosome; PML body; late endosome; P-body; phagophore assembly site; nucleoplasm; aggresome; autophagosome; amphisome; endoplasmic reticulum; inclusion body; lysosome; sperm midpiece; extracellular exosome; cytoplasmic vesicle; nucleus; cytosol; intracellular membrane-bounded organelle; autolysosome; mitochondrion; sarcomere; Lewy body;
Biological process	apoptotic process; protein localization; cell differentiation; positive regulation of protein phosphorylation; intracellular signal transduction; ubiquitin-dependent protein catabolic process; regulation of mitochondrion organization; protein heterooligomerization; immune system process; response to stress; regulation of Ras protein signal transduction; negative regulation of apoptotic process; autophagy; endosomal transport; regulation of protein complex stability; autophagy of mitochondrion; positive regulation of apoptotic process; regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; protein phosphorylation; mitophagy; response to mitochondrial depolarisation; macroautophagy; endosome organization; protein localization to perinuclear region of cytoplasm; response to ischemia; mitochondrion organization; aggrephagy; selective autophagy; interleukin-1-mediated signaling pathway; positive regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	8878
	18412
	ENSG00000161011; ENSG00000284099
	ENSMUSG00000015837
	Q13501
	Q64337
	NM_001142298; NM_001142299; NM_003900
	NM_001290769; NM_011018
	NP_001135770; NP_001135771; NP_003891
	NP_001277698; NP_035148
	Wikidata
View/Edit Human	View/Edit Mouse

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.

Mutations in SQSTM1 are a common cause of Paget's disease of bone.