STX8

STX8
Identifiers
Aliases	STX8, CARB, syntaxin 8
External IDs	OMIM: 604203; MGI: 1890156; HomoloGene: 37973; GeneCards: STX8; OMA:STX8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	9,576,591 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,097,974 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; Achilles tendon; ; gastric mucosa; ; oocyte; ; islet of Langerhans; ; tibial arteries; ; muscle layer of sigmoid colon; ; muscle of thigh;
	Top expressed in
	vestibular membrane of cochlear duct; ; spermatid; ; facial motor nucleus; ; spermatocyte; ; motor neuron; ; seminiferous tubule; ; epithelium of lens; ; right lung lobe; ; saccule; ; transitional epithelium of urinary bladder;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein binding; chloride channel inhibitor activity; syntaxin binding; ubiquitin protein ligase binding; SNARE binding;
Cellular component	integral component of membrane; recycling endosome; vesicle; endosome; late endosome; membrane; late endosome membrane; integral component of plasma membrane; lysosomal membrane; trans-Golgi network; early endosome; endoplasmic reticulum; perinuclear region of cytoplasm; cytosol; SNARE complex; phagocytic vesicle; endomembrane system;
Biological process	endosome to lysosome transport; vesicle docking; early endosome to late endosome transport; intracellular protein transport; vesicle-mediated transport; regulation of protein localization to plasma membrane; vesicle fusion; cellular response to interferon-gamma;
	Sources:Amigo / QuickGO
Orthologs
	9482
	55943
	ENSG00000170310
	ENSMUSG00000020903
	Q9UNK0
	O88983
	NM_004853
	NM_018768; NM_001356314; NM_001361350; NM_001361351; NM_001361352
	NP_004844
	NP_061238; NP_001343243; NP_001348279; NP_001348280; NP_001348281
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene.

Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.