Sulpiride

Sulpiride
Clinical data
Trade names	Dogmatil, Others
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (tablets, capsules, solution), intramuscular injection
ATC code	N05AL01 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: POM (Prescription only); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	25–40%
Protein binding	<40%
Metabolism	Not metabolized; 95% is exerted as the unchanged drug
Elimination half-life	6–8 hours
Excretion	Urine (70–90%),; Feces.
Identifiers
	IUPAC name N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide;
CAS Number	15676-16-1 ;
PubChem CID	5355;
IUPHAR/BPS	5501;
DrugBank	DB00391 ;
ChemSpider	5162 ;
UNII	7MNE9M8287;
KEGG	D01226 ;
ChEMBL	ChEMBL26 ;
CompTox Dashboard (EPA)	DTXSID1042574 ;
ECHA InfoCard	100.036.124
Chemical and physical data
Formula	C15H23N3O4S
Molar mass	341.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NS(=O)(=O)c1ccc(OC)c(c1)C(=O)NCC1CCCN1CC;
	InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key:BGRJTUBHPOOWDU-UHFFFAOYSA-N ;
	(verify)

Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic) medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and is sometimes used in low dosage to treat anxiety and dysthymia.

The drug is chemically and clinically similar to amisulpride. Levosulpiride is its purified levo-isomer and is sold in some countries for similar purposes.

Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. It is not approved in the United States, Canada, or Australia.