Syntrophin, alpha 1

SNTA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QAV, 1Z86, 1Z87, 2ADZ, 2PDZ, 4HOP
Identifiers
Aliases	SNTA1, LQT12, SNT1, TACIP1, dJ1187J4.5, Syntrophin, alpha 1, syntrophin alpha 1
External IDs	OMIM: 601017; MGI: 101772; HomoloGene: 2331; GeneCards: SNTA1; OMA:SNTA1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,443,763 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,250,019 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; right auricle of heart; ; left ventricle; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; Amygdala; ; right lobe of thyroid gland;
	Top expressed in
	muscle of thigh; ; extensor digitorum longus muscle; ; triceps brachii muscle; ; ankle; ; sternocleidomastoid muscle; ; skeletal muscle tissue; ; plantaris muscle; ; medial head of gastrocnemius muscle; ; temporal muscle; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; nitric-oxide synthase binding; transmembrane transporter binding; ATPase binding; structural molecule activity; calmodulin binding; protein binding; actin binding; PDZ domain binding;
Cellular component	cytoplasm; lateral plasma membrane; membrane; neuromuscular junction; plasma membrane; intracellular anatomical structure; cell junction; sarcolemma; syntrophin complex; cytoskeleton; protein-containing complex; dystrophin-associated glycoprotein complex; synapse;
Biological process	muscle contraction; negative regulation of peptidyl-cysteine S-nitrosylation; ventricular cardiac muscle cell action potential; regulation of heart rate; regulation of sodium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
	6640
	20648
	ENSG00000101400
	ENSMUSG00000027488
	Q13424
	Q61234
	NM_003098
	NM_009228
	NP_003089
	NP_033254
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1-syntrophin is a protein that in humans is encoded by the SNTA1 gene. Alpha-1 syntrophin is a signal transducing adaptor protein and serves as a scaffold for various signaling molecules. Alpha-1 syntrophin contains a PDZ domain, two Pleckstrin homology domain and a 'syntrophin unique' domain.