TCF4

TCF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KWF
Identifiers
Aliases	TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19, FECD3, transcription factor 4, CDG2T
External IDs	OMIM: 602272; MGI: 98506; HomoloGene: 2407; GeneCards: TCF4; OMA:TCF4 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	55,664,787 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	69,689,079 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; skin of hip; ; pericardium; ; entorhinal cortex; ; parietal lobe; ; Achilles tendon; ; postcentral gyrus; ; Brodmann area 23; ; synovial joint; ; ganglionic eminence;
	Top expressed in
	Rostral migratory stream; ; ganglionic eminence; ; medial ganglionic eminence; ; subiculum; ; ventricular zone; ; barrel cortex; ; lobe of cerebellum; ; dermis; ; internal carotid artery; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; protein C-terminus binding; protein binding; identical protein binding; TFIIB-class transcription factor binding; protein heterodimerization activity; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex;
Biological process	cell differentiation; regulation of transcription, DNA-templated; protein-DNA complex assembly; transcription, DNA-templated; nervous system development; positive regulation of transcription, DNA-templated; DNA-templated transcription, initiation; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; positive regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6925
	21413
	ENSG00000196628
	ENSMUSG00000053477
	P15884
	Q60722
NM_001083962; NM_001243226; NM_001243227; NM_001243228; NM_001243230;
	NM_001243231; NM_001243232; NM_001243233; NM_001243234; NM_001243235; NM_001243236; NM_001306207; NM_001306208; NM_003199; NM_001330604; NM_001330605; NM_001348211; NM_001348212; NM_001348213; NM_001348214; NM_001348215; NM_001348216; NM_001348217; NM_001348218; NM_001348219; NM_001348220; NM_001369572; NM_001369573; NM_001369574; NM_001369575; NM_001369576; NM_001369577; NM_001369578; NM_001369579; NM_001369580; NM_001369581; NM_001369582; NM_001369583; NM_001369584; NM_001369585; NM_001369586; NM_001369567; NM_001369568; NM_001369569; NM_001369570; NM_001369571
NM_001083967; NM_013685; NM_001361126; NM_001361127; NM_001361128;
	NM_001361129
NP_001077431; NP_001230155; NP_001230156; NP_001230157; NP_001230159;
	NP_001230160; NP_001230161; NP_001230162; NP_001230163; NP_001230164; NP_001230165; NP_001293136; NP_001293137; NP_001317533; NP_001317534; NP_003190; NP_001335140; NP_001335141; NP_001335142; NP_001335143; NP_001335144; NP_001335145; NP_001335146; NP_001335147; NP_001335148; NP_001335149; NP_001356501; NP_001356502; NP_001356503; NP_001356504; NP_001356505; NP_001356506; NP_001356507; NP_001356508; NP_001356509; NP_001356510; NP_001356511; NP_001356512; NP_001356513; NP_001356514; NP_001356515; NP_001356496; NP_001356497; NP_001356498; NP_001356499; NP_001356500
NP_001077436; NP_038713; NP_001348055; NP_001348056; NP_001348057;
	NP_001348058
	Wikidata
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Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2.