TFB1M

TFB1M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GC5, 4GC9
Identifiers
Aliases	TFB1M, CGI75, mtTFB, mtTFB1, CGI-75, transcription factor B1, mitochondrial
External IDs	OMIM: 607033; MGI: 2146851; HomoloGene: 9343; GeneCards: TFB1M; OMA:TFB1M - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	155,314,493 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	3,608,056 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; left testis; ; right testis; ; right lobe of liver; ; testicle; ; Achilles tendon; ; mucosa of transverse colon;
	Top expressed in
	lumbar spinal ganglion; ; primary oocyte; ; seminiferous tubule; ; zygote; ; Paneth cell; ; lacrimal gland; ; endocardial cushion; ; secondary oocyte; ; left lobe of liver; ; atrioventricular junction;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; rRNA methyltransferase activity; protein binding; rRNA (adenine-N6,N6-)-dimethyltransferase activity; RNA binding;
Cellular component	mitochondrial matrix; mitochondrial nucleoid; mitochondrion;
Biological process	rRNA processing; methylation; mitochondrion organization; regulation of transcription, DNA-templated; rRNA methylation; transcription, DNA-templated; rRNA modification;
	Sources:Amigo / QuickGO
Orthologs
	51106
	224481
	ENSG00000029639
	ENSMUSG00000036983
	Q8WVM0
	Q8JZM0
	NM_016020; NM_001350501; NM_001350502
	NM_146074
	NP_057104; NP_001337430; NP_001337431
	NP_666186
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.

TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.

Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM. There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.