TFCP2

TFCP2
Identifiers
Aliases	TFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs	OMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,173,135 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,449,889 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; superficial temporal artery; ; ventricular zone; ; monocyte; ; ganglionic eminence; ; granulocyte; ; rectum; ; gastrocnemius muscle; ; gonad; ; islet of Langerhans;
	Top expressed in
	neural layer of retina; ; pineal gland; ; genital tubercle; ; tail of embryo; ; ventricular zone; ; perirhinal cortex; ; renal corpuscle; ; entorhinal cortex; ; right kidney; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein C-terminus binding; protein binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; cytosol; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; mRNA transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7024
	21422
	ENSG00000135457
	ENSMUSG00000009733
	Q12800
	Q9ERA0
	NM_005653; NM_001173452; NM_001173453
	NM_001289603; NM_033476; NM_001355497
	NP_001166923; NP_001166924; NP_005644
	NP_001276532; NP_258437; NP_001342426
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcinoma. LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.