TMC6

TMC6
Identifiers
Aliases	TMC6, EV1, EVER1, EVIN1, LAK-4P, transmembrane channel like 6, TNRC6C-AS1, lnc
External IDs	OMIM: 605828; MGI: 1098686; HomoloGene: 5258; GeneCards: TMC6; OMA:TMC6 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,132,407 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,673,024 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; C1 segment; ; lymph node; ; spleen; ; apex of heart; ; sural nerve; ; upper lobe of left lung; ; mucosa of transverse colon; ; buccal mucosa cell; ; appendix;
	Top expressed in
	granulocyte; ; thymus; ; blood; ; otic placode; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; saccule; ; lip; ; tibiofemoral joint; ; Ileal epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ion channel activity; mechanosensitive ion channel activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; nuclear membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; plasma membrane; specific granule membrane; tertiary granule membrane; integral component of plasma membrane;
Biological process	ion transport; neutrophil degranulation; transport; biological process; ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	11322
	217353
	ENSG00000141524
	ENSMUSG00000025572
	Q7Z403
	Q7TN60
NM_001127198; NM_007267; NM_001321185; NM_001374593; NM_001374594;
	NM_001375353; NM_001375354; NM_001374596
	NM_145439; NM_181321
NP_001120670; NP_001308114; NP_009198; NP_001361522; NP_001361523;
	NP_001362282; NP_001362283; NP_001361525
	NP_663414
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane channel-like protein 6 is a protein that in humans is encoded by the TMC6 gene. In vivo, TMC6 and its homolog TMC8, interact and form a complex with the zinc transporter 1 (SLC30A1) and localize mostly to the endoplasmic reticulum, but also to the nuclear membrane and Golgi apparatus.

Inactivating mutations in TMC6 or TMC8 have been implicated as the genetic cause of the rare skin disorder epidermodysplasia verruciformis, which is characterized by abnormal susceptibility to human papillomaviruses (HPVs) of the skin resulting in the growth of scaly macules and papules, particularly on the hands and feet.