Triadin

TRDN
Identifiers
Aliases	TRDN, CPVT5, TDN, TRISK, triadin, CARDAR
External IDs	OMIM: 603283; MGI: 1924007; HomoloGene: 38137; GeneCards: TRDN; OMA:TRDN - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	123,637,093 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	33,352,705 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; vastus lateralis muscle; ; glutes; ; apex of heart; ; body of tongue; ; triceps brachii muscle;
	Top expressed in
	ankle; ; triceps brachii muscle; ; muscle of thigh; ; extraocular muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; interventricular septum; ; vastus lateralis muscle; ; tibialis anterior muscle; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding; signaling receptor binding; transmembrane transporter binding;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; membrane; junctional sarcoplasmic reticulum membrane; sarcoplasmic reticulum; endoplasmic reticulum; sarcoplasmic reticulum membrane; junctional membrane complex; sarcoplasmic reticulum lumen; cytosol; plasma membrane;
Biological process	positive regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of cardiac conduction; muscle contraction; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of release of sequestered calcium ion into cytosol; cellular calcium ion homeostasis; endoplasmic reticulum membrane organization; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; ion transmembrane transport; cytoplasmic microtubule organization; regulation of cell communication by electrical coupling; heart contraction; regulation of cardiac muscle cell membrane potential; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	10345
	76757
	ENSG00000186439
	ENSMUSG00000019787
	Q13061
	E9Q9K5
	NM_001251987; NM_001256020; NM_001256021; NM_001256022; NM_006073
	NM_029726; NM_001364696; NM_001364697
NP_001238916; NP_001242949; NP_001242950; NP_001242951; NP_006064;
	NP_001242950.1
	NP_084002; NP_001351625; NP_001351626
	Wikidata
View/Edit Human	View/Edit Mouse

Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum) section of Triadin has areas of highly charged amino acid residues that act as luminal Ca²⁺ receptors. Triadin is also able to sense luminal Ca²⁺ concentrations by mediating interactions between RYR2 and CASQ2. Triadin has several different forms; Trisk 95 and Trisk 51, which are expressed in skeletal muscle, and Trisk 32 (CT1), which is mainly expressed in cardiac muscle.