TRIM6

TRIM6
Identifiers
Aliases	TRIM6, RNF89, tripartite motif containing 6
External IDs	OMIM: 607564; MGI: 2137352; HomoloGene: 14381; GeneCards: TRIM6; OMA:TRIM6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,612,958 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	103,884,359 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; human kidney; ; parotid gland; ; palpebral conjunctiva; ; germinal epithelium; ; tibia; ; testicle; ; parietal pleura;
	Top expressed in
	yolk sac; ; morula; ; blastocyst; ; embryo; ; epiblast; ; primitive streak; ; spermatocyte; ; embryo; ; tail of embryo; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein tyrosine kinase binding; ubiquitin protein ligase activity; zinc ion binding; transcription factor binding; metal ion binding; protein binding; protein kinase binding; transferase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; nucleus;
Biological process	positive regulation of transcription regulatory region DNA binding; cellular response to virus; positive regulation of type I interferon-mediated signaling pathway; regulation of NIK/NF-kappaB signaling; free ubiquitin chain polymerization; cellular response to interferon-beta; protein trimerization; protein polyubiquitination; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; negative regulation of stem cell differentiation; response to lipopolysaccharide; negative regulation of viral genome replication; positive regulation of gene expression; positive regulation of peptidyl-threonine phosphorylation; protein ubiquitination; negative regulation of transcription, DNA-templated; positive regulation of defense response to virus by host; viral process;
	Sources:Amigo / QuickGO
Orthologs
	117854
	94088
	ENSG00000121236
	ENSMUSG00000072244
	Q9C030
	Q8BGE7
	NM_058166; NM_001003818; NM_001198644; NM_001198645
	NM_001013616
	NP_001003818; NP_001185573; NP_001185574; NP_477514
	NP_001013637
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.