TRIP13

TRIP13
Identifiers
Aliases	TRIP13, 16E1BP, thyroid hormone receptor interactor 13, MVA3, OOMD9
External IDs	OMIM: 604507; MGI: 1916966; HomoloGene: 3125; GeneCards: TRIP13; OMA:TRIP13 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	919,357 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,085,903 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; oocyte; ; gonad; ; secondary oocyte; ; right testis; ; left testis; ; ventricular zone; ; mucosa of paranasal sinus; ; sperm; ; testicle;
	Top expressed in
	otic placode; ; primitive streak; ; abdominal wall; ; endothelial cell of lymphatic vessel; ; Paneth cell; ; endocardial cushion; ; saccule; ; condyle; ; somite; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; transcription coregulator activity; ATP binding; identical protein binding;
Cellular component	male germ cell nucleus; nucleus; chromosome;
Biological process	meiosis; reciprocal meiotic recombination; male meiosis I; cell differentiation; oocyte maturation; double-strand break repair; transcription by RNA polymerase II; synaptonemal complex assembly; spermatogenesis; female meiosis I; spermatid development; oogenesis; mitotic spindle assembly checkpoint signaling; regulation of nucleic acid-templated transcription; meiotic recombination checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	9319
	69716
	ENSG00000071539
	ENSMUSG00000021569
	Q15645
	Q3UA06
	NM_001166260; NM_004237
	NM_027182
	NP_001159732; NP_004228
	NP_081458
	Wikidata
View/Edit Human	View/Edit Mouse

TRIP13 is a mammalian gene that encodes the thyroid receptor-interacting protein 13. In budding yeast, the analog for TRIP13 is PCH2. TRIP13 is a member of the AAA+ ATPase family, a family known for mechanical forces derived from ATP hydrolase reactions. The TRIP13 gene has been shown to interact with a variety of proteins and implicated in a few diseases, notably interacting with the ligand binding domain of thyroid hormone receptors, and may play a role in early-stage non-small cell lung cancer. However, recent evidence implicates TRIP13 in various cell cycle phases, including meiosis G2/Prophase and during the Spindle Assembly checkpoint (SAC). Evidence shows regulation to occur through the HORMA domains, including Hop1, Rev7, and Mad2. Of note, Mad2's involvement in the SAC is shown to be affected by TRIP13 Due to TRIP13's role in cell cycle arrest and progression, it may present opportunity as a therapeutic candidate for cancers.