Tiapride

Tiapride
Clinical data
Trade names	Tiapridal
Routes of; administration	Oral (tablets), IM, IV
ATC code	N05AL03 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	~75% (oral) (Tmax = 1 hour)
Protein binding	Negligible
Elimination half-life	2.9–3.6 hours
Excretion	Urine (70% as unchanged tiapride)
Identifiers
	IUPAC name N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide;
CAS Number	51012-32-9 ;
PubChem CID	5467;
ChemSpider	5268 ;
UNII	LAH70H9JPH;
KEGG	D08590 ;
ChEMBL	ChEMBL84158 ;
CompTox Dashboard (EPA)	DTXSID0023664 ;
ECHA InfoCard	100.051.717
Chemical and physical data
Formula	C15H24N2O4S
Molar mass	328.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC;
	(verify)

Tiapride is a drug that selectively blocks D₂ and D₃ dopamine receptors in the brain. It is used to treat a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects.

Clinical data

Trade names	Tiapridal
Routes of administration	Oral (tablets), IM, IV
ATC code	N05AL03 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances) In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	~75% (oral) (T_max = 1 hour)
Protein binding	Negligible
Elimination half-life	2.9–3.6 hours
Excretion	Urine (70% as unchanged tiapride)
Identifiers
IUPAC name N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
CAS Number	51012-32-9^Y
PubChem CID	5467
ChemSpider	5268^Y
UNII	LAH70H9JPH
KEGG	D08590^Y
ChEMBL	ChEMBL84158^Y
CompTox Dashboard (EPA)	DTXSID0023664
ECHA InfoCard	100.051.717
Chemical and physical data
Formula	C₁₅H₂₄N₂O₄S
Molar mass	328.43 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCNC(=O)C1=C(C=CC(=C1)S(=O)(=O)C)OC
(verify)