Torasemide

Torasemide
Clinical data
Trade names	Demadex, Tortas, Wator
Other names	Torsemide, Torsemide (USAN US)
AHFS/Drugs.com	Monograph
MedlinePlus	a601212
License data	US DailyMed: Torsemide;
Routes of; administration	By mouth, intraveneous
Drug class	Loop diuretic
ATC code	C03CA04 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Liver (80%)
Elimination half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
	IUPAC name N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide;
CAS Number	56211-40-6 ;
PubChem CID	41781;
IUPHAR/BPS	7312;
DrugBank	DB00214 ;
ChemSpider	38123 ;
UNII	W31X2H97FB;
KEGG	D00382 ;
ChEBI	CHEBI:9637 ;
ChEMBL	ChEMBL1148 ;
CompTox Dashboard (EPA)	DTXSID2023690 ;
ECHA InfoCard	100.164.924
Chemical and physical data
Formula	C16H20N4O3S
Molar mass	348.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cc(C)ccc2;
	InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) ; Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N ;
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Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. It is a less preferred treatment for high blood pressure. It is taken by mouth or by injection into a vein.

Common side effects include headache, increased urination, diarrhea, cough, and dizziness. Other side effects may include hearing loss and low blood potassium. Torasemide is a sulfonamide and loop diuretic. Use is not recommended in pregnancy or breastfeeding. It works by decreasing the reabsorption of sodium by the kidneys.

Torasemide was patented in 1974 and came into medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2022, it was the 184th most commonly prescribed medication in the United States, with more than 2 million prescriptions.