U.S. Route 22 in Pennsylvania

U.S. Route 22
U.S. Route 22
	US 22 highlighted in red and business routes in blue
Route information
	Maintained by PennDOT and DRJTBC
Length	338.20 mi (544.28 km)
Existed	1926–present
Major junctions
West end	US 22 at the West Virginia state line
	I-376 / Orange Belt / PA 60 in Robinson Township; I-79 near Carnegie; ; I-279 / US 19 Truck in Pittsburgh; ; ; I-76 Toll / Penna Turnpike / US 22 Bus. in Monroeville; I-99 / US 220 in Duncansville; I-81 / US 322 near Harrisburg; I-83 / US 322 in Lower Paxton Township; I-78 from Fredericksburg to Kuhnsville; ; I-476 Toll / Penna Turnpike NE Extension in South Whitehall Township;
East end	US 22 at the New Jersey state line
Location
Country	United States
State	Pennsylvania
Counties	Washington, Allegheny, Westmoreland, Indiana, Cambria, Blair, Huntingdon, Mifflin, Juniata, Perry, Dauphin, Lebanon, Berks, Lehigh, Northampton
Highway system
	United States Numbered Highway System; List; Special; Divided; Pennsylvania State Route System; Interstate; US; State; Scenic; Legislative;

U.S. Route 22 (US 22) is an east–west United States Numbered Highway that stretches from Cincinnati, Ohio, in the west, to Newark, New Jersey, in the east. In Pennsylvania, the route runs for 338.20 miles (544.28 km) between the West Virginia state line in Washington County, where it is a freeway through the western suburbs of Pittsburgh, and then runs east to Easton and the New Jersey state line in the Lehigh Valley region of eastern Pennsylvania.

Much of US 22 in Pennsylvania follows the route of the historic William Penn Highway. The portion from the Pennsylvania Route 66 (PA 66) interchange near Delmont east to the Interstate 81 (I-81) interchange near Harrisburg is the main part of Corridor M of the Appalachian Development Highway System, although a large portion near the center of the route has not yet been upgraded to a four-lane divided highway.

Between Fredericksburg and just west of Allentown, US 22 runs concurrently with I-78. From Allentown to the New Jersey state line, the route is a freeway named the Lehigh Valley Thruway.