U.S. Route 278 in South Carolina

U.S. Highway 278
U.S. Highway 278
	Route of US 278 in South Carolina highlighted in red
Route information
	Auxiliary route of US 78
	Maintained by SCDOT
Length	146.130 mi (235.173 km)
Existed	1965–present
Tourist; routes	Hilton Head Scenic Byway
Major junctions
West end	US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 at the Georgia state line near North Augusta
	US 25 / SC 121 in North Augusta; I-520 in North Augusta; US 1 / US 78 / SC 125 / SC 421 near Clearwater; US 301 / SC 125 in Allendale; US 321 in Fairfax; US 601 / SC 363 in Hampton; US 17 / SC 336 in Ridgeland; I-95 near Hardeeville;
East end	; US 278 Bus. in Hilton Head Island
Location
Country	United States
State	South Carolina
Counties	Aiken, Barnwell, Allendale, Hampton, Jasper, Beaufort
Highway system
	United States Numbered Highway System; List; Special; Divided; South Carolina State Highway System; Interstate; US; State; Scenic;

U.S. Route 278 (US 278) is a 146.130-mile (235.173 km) east–west United States highway that traverses through the South Carolina Lowcountry, from North Augusta to Hilton Head Island.