U.S. Route 60 in Missouri
| US 60 highlighted in red | ||||
| Route information | ||||
| Maintained by MoDOT | ||||
| Length | 341.248 mi (549.185 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| West end | US 60 at the Oklahoma state line | |||
| 
 | ||||
| East end | US 60 / US 62 at the Illinois state line | |||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Counties | Newton, Barry, Lawrence, Christian, Greene, Webster, Wright, Texas, Howell, Shannon, Carter, Butler, Stoddard, New Madrid, Scott, Mississippi | |||
| Highway system | ||||
| 
 | ||||
U.S. Route 60 (US 60) is a part of the United States Numbered Highway System that runs from Brenda, Arizona, east to Virginia Beach, Virginia. In the state of Missouri, US 60 is a main east–west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border.