U.S. Route 63 in Missouri
| US 63 highlighted in red | ||||
| Route information | ||||
| Maintained by MoDOT | ||||
| Length | 337.748 mi (543.553 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| South end | US 63 at the Arkansas state line | |||
| 
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| North end | US 63 at the Iowa state line | |||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Counties | Oregon, Howell, Texas, Phelps, Maries, Osage, Cole, Callaway, Boone, Randolph, Macon, Adair, Schuyler | |||
| Highway system | ||||
| 
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U.S. Route 63 (US 63) is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.