U.S. Route 50 in Missouri
| US 50 highlighted in red | ||||
| Route information | ||||
| Maintained by MoDOT | ||||
| Length | 263.58 mi (424.19 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| West end | I-435 / US-50 in Leawood, KS | |||
| 
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| East end | I-255 / US 50 towards Columbia, IL | |||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Counties | Jackson, Johnson, Pettis, Morgan, Moniteau, Cole, Osage, Gasconade, Franklin, St. Louis | |||
| Highway system | ||||
| 
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U.S. Route 50 (US 50) is a major east–west route in the state of Missouri. It is also known as the Rex M. Whitton Expressway in the capital of Missouri, Jefferson City.