U.S. Route 50 in Illinois
| US 50 highlighted in red | ||||
| Route information | ||||
| Maintained by IDOT | ||||
| Length | 165.79 mi (266.81 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| West end | I-255 / US 50 at the Missouri state line in Columbia | |||
| East end | US 50 at the Indiana state line near Lawrenceville | |||
| Location | ||||
| Country | United States | |||
| State | Illinois | |||
| Counties | Monroe, St. Clair, Clinton, Marion, Clay, Richland, Lawrence | |||
| Highway system | ||||
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U.S. Route 50 (US 50) in the state of Illinois is an east–west highway across the southern portion of the state. It runs from the Jefferson Barracks Bridge, over the Mississippi River, to Missouri east, to the Red Skelton Memorial Bridge, over the Wabash River and to Indiana. This is a distance of 165.79 miles (266.81 km).