U.S. Route 78 in Alabama

U.S. Route 78
U.S. Route 78
State Route 4
	US 78 highlighted in red
Route information
	Maintained by ALDOT
Existed	1926–present
Major junctions
West end	I-22 / US 78 at the Mississippi state line
	US 43 / US 278 in Hamilton; I-22 in Graysville; I-20 / I-59 in Birmingham; US 11 in Birmingham; I-65 in Birmingham; I-20 in Leeds; US 411 in Leeds; I-20 in Pell City; US 231 in Pell City; US 431 in Oxford;
East end	US 78 at the Georgia state line
Location
Country	United States
State	Alabama
Counties	Marion, Walker, Jefferson, Saint Clair, Talladega, Calhoun, Cleburne
Highway system
	United States Numbered Highway System; List; Special; Divided; Alabama State Highway System; Interstate; US; State;

U.S. Route 78 (US 78) is a major east–west U.S. Highway across the central part of Alabama. It is internally designated State Route 4 (SR 4) by the Alabama Department of Transportation (ALDOT), though the only section of SR 4 that is signed is along portions mainly west of Jasper. The section from the Mississippi state line to near Graysville is concurrent with Interstate 22 (I-22); from Graysville south to Birmingham, US 78 takes its original routing. East of Birmingham to the Georgia state line, US 78 has been replaced as a major through-route by I-20. The two routes roughly parallel each other, with junctions at Leeds and Pell City.

West of Jasper, old US 78 is signed as SR 118 to Guin, and the segment from Guin northward to I-22 at Hamilton is signed as US 43/US 278.