U.S. Route 78 in Mississippi

U.S. Highway 78
U.S. Highway 78
Route information
	Maintained by MDOT
Length	117.4 mi (188.9 km)
Existed	November 11, 1926–present
Major junctions
West end	US 78 / SR 4 at the Tennessee state line
	I-22 / I-269 / MS 304 in Byhalia; MS 4 / MS 7 in Holly Springs; MS 178 at various locations; MS 15 / MS 30 in New Albany; US 45 in Tupelo; MS 23 in Tremont;
East end	I-22 / US 78 / SR 4 at the Alabama state line
Location
Country	United States
State	Mississippi
Counties	DeSoto, Marshall, Benton, Union, Pontotoc, Lee, Itawamba
Highway system
	United States Numbered Highway System; List; Special; Divided; Mississippi State Highway System; Interstate; US; State;

U.S. Highway 78 (US 78) is a 117.4 miles (188.9 km) east-west controlled-access highway in northern Mississippi. The section from its intersection with Interstate 269 (I-269) in Byhalia to the Alabama state line runs concurrently with I-22. The highway runs across the northeastern rural part of the state, connecting several population centers.

Mississippi's portion of US 78 is defined in Mississippi Code Annotated § 65-3-3.