UBA1

UBA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P22
Identifiers
Aliases	UBA1, A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, ubiquitin like modifier activating enzyme 1
External IDs	OMIM: 314370; MGI: 98890; HomoloGene: 22002; GeneCards: UBA1; OMA:UBA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	47,215,128 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,549,418 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; mucosa of pharynx; ; ventricular zone; ; right lobe of thyroid gland; ; ganglionic eminence; ; nipple; ; postcentral gyrus; ; right uterine tube; ; spinal ganglia; ; trigeminal ganglion;
	Top expressed in
	tail of embryo; ; ganglionic eminence; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; ventricular zone; ; gastrula; ; epiblast; ; habenula; ; choroid plexus of fourth ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ligase activity; protein binding; ubiquitin-like modifier activating enzyme activity; ATP binding; ubiquitin activating enzyme activity; RNA binding;
Cellular component	cytoplasm; rough endoplasmic reticulum membrane; desmosome; heterochromatin; lysosomal membrane; mitochondrion; endosome membrane; extracellular exosome; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to DNA damage stimulus; protein ubiquitination; ubiquitin-dependent protein catabolic process; protein modification by small protein conjugation; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7317
	22201
	ENSG00000130985
	ENSMUSG00000001924
	P22314; Q5JRS2
	Q02053
	NM_003334; NM_153280
	NM_001136085; NM_001276316; NM_001276317; NM_009457
	NP_003325; NP_695012
	NP_001129557; NP_001263245; NP_001263246; NP_033483
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.