UBA2

UBA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y8Q, 1Y8R, 2PX9, 3KYC, 3KYD, 4W5V
Identifiers
Aliases	UBA2, ARX, SAE2, HRIHFB2115, ubiquitin like modifier activating enzyme 2
External IDs	OMIM: 613295; MGI: 1858313; HomoloGene: 4018; GeneCards: UBA2; OMA:UBA2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	34,471,251 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	33,869,024 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; gonad; ; left coronary artery; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	otic placode; ; otic vesicle; ; saccule; ; primitive streak; ; renal corpuscle; ; somite; ; medial ganglionic eminence; ; abdominal wall; ; mandibular prominence; ; superior cervical ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleotide binding; enzyme activator activity; ubiquitin-like modifier activating enzyme activity; transcription factor binding; protein binding; SUMO activating enzyme activity; magnesium ion binding; ATP binding; SUMO binding; small protein activating enzyme binding; ubiquitin-like protein conjugating enzyme binding; protein heterodimerization activity; acid-amino acid ligase activity; transferase activity;
Cellular component	nucleus; SUMO activating enzyme complex; nucleoplasm; cytoplasm;
Biological process	protein sumoylation; positive regulation of catalytic activity; protein modification by small protein conjugation;
	Sources:Amigo / QuickGO
Orthologs
	10054
	50995
	ENSG00000126261
	ENSMUSG00000052997
	Q9UBT2
	Q9Z1F9
	NM_005499
	NM_016682
	NP_005490
	NP_057891
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene.

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.