UBE2C

UBE2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I7K, 4YII, 5A31
Identifiers
Aliases	UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs	OMIM: 605574; MGI: 1915862; HomoloGene: 5096; GeneCards: UBE2C; OMA:UBE2C - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,816,957 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,620,742 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; oocyte; ; mucosa of transverse colon; ; gonad; ; bone marrow; ; secondary oocyte; ; thymus; ; trabecular bone;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; tail of embryo; ; zygote; ; genital tubercle; ; medial ganglionic eminence; ; ventricular zone; ; somite; ; otic placode; ; abdominal wall; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding;
Cellular component	cytoplasm; nucleoplasm; anaphase-promoting complex; cytosol; plasma membrane; ubiquitin ligase complex; nucleus;
Biological process	free ubiquitin chain polymerization; ubiquitin-dependent protein catabolic process; exit from mitosis; positive regulation of exit from mitosis; protein K11-linked ubiquitination; cell division; protein K48-linked ubiquitination; regulation of mitotic metaphase/anaphase transition; cell cycle; anaphase-promoting complex-dependent catabolic process; positive regulation of ubiquitin protein ligase activity; protein ubiquitination; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	11065
	68612
	ENSG00000175063
	ENSMUSG00000001403
	O00762; Q5TZN3
	Q9D1C1
NM_001281741; NM_001281742; NM_007019; NM_181799; NM_181800;
	NM_181801; NM_181802; NM_181803
	NM_026785
NP_001268670; NP_001268671; NP_008950; NP_861515; NP_861516;
	NP_861517; NP_008950.1
	NP_081061
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.