UBE4B

UBE4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KRE, 3L1X, 3L1Z
Identifiers
Aliases	UBE4B, E4, HDNB1, UBOX3, UFD2, UFD2A, ubiquitination factor E4B
External IDs	OMIM: 613565; MGI: 1927086; HomoloGene: 107623; GeneCards: UBE4B; OMA:UBE4B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	10,181,239 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,426,749 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; skin of thigh; ; hair follicle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gastric mucosa; ; gastrocnemius muscle; ; inferior olivary nucleus; ; Skeletal muscle tissue of rectus abdominis; ; right adrenal cortex;
	Top expressed in
	tail of embryo; ; genital tubercle; ; secondary oocyte; ; zygote; ; internal carotid artery; ; external carotid artery; ; yolk sac; ; facial motor nucleus; ; renal corpuscle; ; ureter;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; ATPase binding; ubiquitin-protein transferase activity; enzyme binding; ATP binding; transferase activity; ubiquitin-ubiquitin ligase activity; protein binding;
Cellular component	ubiquitin ligase complex; nucleus; cytoplasm;
Biological process	protein monoubiquitination; response to endoplasmic reticulum stress; ventricular trabecula myocardium morphogenesis; protein ubiquitination; neuron projection development; granzyme-mediated apoptotic signaling pathway; response to UV; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10277
	63958
	ENSG00000130939
	ENSMUSG00000028960
	O95155
	Q9ES00
	NM_001105562; NM_006048
	NM_022022
	NP_001099032; NP_006039
	NP_071305; NP_001391797; NP_001391798
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.