UNC5C

UNC5C
Identifiers
Aliases	UNC5C, UNC5H3, unc-5 netrin receptor C
External IDs	OMIM: 603610; MGI: 1095412; HomoloGene: 2765; GeneCards: UNC5C; OMA:UNC5C - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	95,549,206 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	141,540,685 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; tibia; ; internal globus pallidus; ; Pons; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; testicle; ; right coronary artery; ; C1 segment; ; superior vestibular nucleus;
	Top expressed in
	genital tubercle; ; secondary oocyte; ; supraoptic nucleus; ; zygote; ; otic vesicle; ; ethmoid bone; ; suprachiasmatic nucleus; ; ascending aorta; ; cerebellar vermis; ; cribriform plate;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	netrin receptor activity; netrin receptor activity involved in chemorepulsion; protein binding; protein kinase binding; tubulin binding;
Cellular component	integral component of membrane; neuron projection; cell junction; plasma membrane; synapse; membrane; axon; dendrite; growth cone; soma; lamellipodium; filopodium; cell surface; cell projection;
Biological process	positive regulation of apoptotic process; netrin-activated signaling pathway; multicellular organism development; brain development; regulation of cell migration; signal transduction; anterior/posterior axon guidance; axon guidance; apoptotic process; negative chemotaxis; chemorepulsion of axon; dorsal root ganglion development;
	Sources:Amigo / QuickGO
Orthologs
	8633
	22253
	ENSG00000182168
	ENSMUSG00000059921
	O95185
	O08747
	NM_003728
	NM_001293561; NM_009472
	NP_003719
	NP_001280490; NP_033498
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.