Umeclidinium bromide

Umeclidinium bromide
Clinical data
Trade names	Incruse Ellipta
Other names	GSK573719A
License data	US DailyMed: Umeclidinium bromide;
Routes of; administration	Inhalation (DPI)
ATC code	R03BB07 (WHO) ; R03AL03 (WHO) (+vilanterol);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	~89%
Metabolism	Liver (CYP2D6)
Elimination half-life	11 hours
Excretion	Feces (58%) and urine (22%)
Identifiers
	IUPAC name Diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol bromide;
CAS Number	869113-09-7;
PubChem CID	11519069;
DrugBank	DB09076;
ChemSpider	9693857;
UNII	7AN603V4JV;
KEGG	D10181;
ChEBI	CHEBI:79040;
CompTox Dashboard (EPA)	DTXSID50235966 ;
ECHA InfoCard	100.166.375
Chemical and physical data
Formula	C29H34BrNO2
Molar mass	508.500 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2.[Br-];
	InChI InChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1; Key:PEJHHXHHNGORMP-UHFFFAOYSA-M;

Umeclidinium bromide, sold under the brand name Incruse Ellipta among others, is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It is also approved for this indication in combination with vilanterol (as umeclidinium bromide/vilanterol), and also as a triple-therapy combination as fluticasone furoate/umeclidinium bromide/vilanterol.

It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 245th most commonly prescribed medication in the United States, with more than 1 million prescriptions.