VAPA

VAPA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RR3
Identifiers
Aliases	VAPA, VAP-33, VAP-A, VAP33, hVAP-33, VAMP associated protein A, VAMP-A
External IDs	OMIM: 605703; MGI: 1353561; HomoloGene: 37824; GeneCards: VAPA; OMA:VAPA - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,960,021 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	65,920,550 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; optic nerve; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; gingival epithelium; ; Pons; ; parotid gland; ; rectum;
	Top expressed in
	Paneth cell; ; medullary collecting duct; ; renal corpuscle; ; atrioventricular valve; ; Gonadal ridge; ; cumulus cell; ; condyle; ; gastrula; ; fossa; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; microtubule binding; signal transducer activity; protein binding; protein heterodimerization activity; cadherin binding; FFAT motif binding;
Cellular component	integral component of membrane; vesicle; endoplasmic reticulum membrane; membrane; microtubule cytoskeleton; endoplasmic reticulum; perinuclear region of cytoplasm; endoplasmic reticulum exit site; cell junction; bicellular tight junction; Golgi membrane; nuclear membrane; nucleus; plasma membrane; azurophil granule membrane;
Biological process	COPII-coated vesicle budding; cell death; membrane fusion; protein folding in endoplasmic reticulum; sphingolipid biosynthetic process; endoplasmic reticulum organization; positive regulation by host of viral genome replication; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein localization to endoplasmic reticulum; negative regulation by host of viral genome replication; neuron projection development; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	9218
	30960
	ENSG00000101558
	ENSMUSG00000024091
	Q9P0L0
	Q9WV55
	NM_003574; NM_194434
	NM_013933; NM_001355402
	NP_003565; NP_919415
	NP_038961; NP_001342331
	Wikidata
View/Edit Human	View/Edit Mouse

VAMP-Associated Protein A ( or Vesicle-Associated Membrane Protein-Associated Protein A) is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.

VAPA is ubiquitously expressed in human tissues and is thought to be involved in membrane trafficking by interaction with SNAREs, in regulation of lipid transport and metabolism, and in the Unfolded Protein Response (UPR).