VAPB

VAPB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MDK, 3IKK
Identifiers
Aliases	VAPB, ALS8, VAMP-B, VAP-B, VAMP (vesicle-associated membrane protein)-associated protein B and C, VAMP associated protein B and C
External IDs	OMIM: 605704; MGI: 1928744; HomoloGene: 36163; GeneCards: VAPB; OMA:VAPB - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	58,451,101 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,626,132 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; Pons; ; superior frontal gyrus; ; Skeletal muscle tissue of rectus abdominis; ; entorhinal cortex; ; secondary oocyte; ; biceps brachii;
	Top expressed in
	muscle of thigh; ; lacrimal gland; ; stroma of bone marrow; ; submandibular gland; ; dorsomedial hypothalamic nucleus; ; digastric muscle; ; transitional epithelium of urinary bladder; ; motor neuron; ; Rostral migratory stream; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; microtubule binding; protein binding; beta-tubulin binding; protein heterodimerization activity; enzyme binding; cadherin binding; FFAT motif binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; endoplasmic reticulum exit site; Golgi membrane; cytoplasm;
Biological process	COPII-coated vesicle budding; cellular calcium ion homeostasis; sphingolipid biosynthetic process; endoplasmic reticulum organization; positive regulation by host of viral genome replication; endoplasmic reticulum unfolded protein response; endoplasmic reticulum to Golgi vesicle-mediated transport; response to unfolded protein; suppression of viral release by host; negative regulation by host of viral genome replication; positive regulation of viral genome replication; negative regulation by virus of viral protein levels in host cell; viral process; modulation by host of viral RNA genome replication; IRE1-mediated unfolded protein response;
	Sources:Amigo / QuickGO
Orthologs
	9217
	56491
	ENSG00000124164
	ENSMUSG00000054455
	O95292
	Q9QY76; Q8BH80
	NM_001195677; NM_004738
	NM_019806
	NP_001182606; NP_004729
	NP_062780
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome. Together with VAPA, it forms the VAP protein family.