VEGF receptor
| VEGF receptor | |
|---|---|
| Identifiers | |
| Symbol | VEGF |
| InterPro | IPR009135 |
| Membranome | 1335 |
| Identifiers | |||||||
|---|---|---|---|---|---|---|---|
| Symbol | FLT1 | ||||||
| Alt. symbols | FLT | ||||||
| NCBI gene | 2321 | ||||||
| HGNC | 3763 | ||||||
| OMIM | 165070 | ||||||
| RefSeq | NM_002019 | ||||||
| UniProt | P17948 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 13 q12 | ||||||
| |||||||
| kinase insert domain receptor (a type III receptor tyrosine kinase) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | KDR | ||||||
| Alt. symbols | FLK1, VEGFR, VEGFR2, CD309 | ||||||
| NCBI gene | 3791 | ||||||
| HGNC | 6307 | ||||||
| OMIM | 191306 | ||||||
| RefSeq | NM_002253 | ||||||
| UniProt | P35968 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 4 q11-q12 | ||||||
| |||||||
| fms-related tyrosine kinase 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FLT4 | ||||||
| Alt. symbols | VEGFR3, PCL | ||||||
| NCBI gene | 2324 | ||||||
| HGNC | 3767 | ||||||
| OMIM | 136352 | ||||||
| RefSeq | NM_002020 | ||||||
| UniProt | P35916 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 5 q34-q35 | ||||||
| |||||||
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).
Inhibitors of VEGFR are used in the treatment of cancer.