VPS26A

VPS26A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FAU
Identifiers
Aliases	VPS26A, HB58, Hbeta58, PEP8A, VPS26, VPS26 retromer complex component A, VPS26, retromer complex component A
External IDs	OMIM: 605506; MGI: 1353654; HomoloGene: 68420; GeneCards: VPS26A; OMA:VPS26A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,174,412 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,322,584 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; parotid gland; ; visceral pleura; ; germinal epithelium; ; skin of thigh; ; skin of hip; ; endothelial cell; ; mucosa of sigmoid colon; ; oral cavity; ; tail of epididymis;
	Top expressed in
	spermatocyte; ; spermatid; ; zygote; ; primary oocyte; ; seminiferous tubule; ; cumulus cell; ; yolk sac; ; secondary oocyte; ; stroma of bone marrow; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; tubular endosome; retromer complex; vesicle; endosome; early endosome; membrane; lysosome; endosome membrane; retromer, cargo-selective complex; cytosol;
Biological process	protein transport; retrograde transport, endosome to Golgi; regulation of macroautophagy; intracellular protein transport; Wnt signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9559
	30930
	ENSG00000122958
	ENSMUSG00000020078
	O75436
	P40336
	NM_001035260; NM_004896; NM_001318944; NM_001318945; NM_001318946
	NM_001113355; NM_133672; NM_001358543
	NP_001030337; NP_001305873; NP_001305874; NP_001305875; NP_004887
	NP_001106826; NP_598433; NP_001345472
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.