Wiskott–Aldrich syndrome protein

WAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CEE, 1EJ5, 1T84, 2A3Z, 2K42, 2OT0
Identifiers
Aliases	WAS, SCNX, THC, THC1, WASPA, WASp, IMD2, Wiskott-Aldrich syndrome, WASP actin nucleation promoting factor
External IDs	OMIM: 300392; MGI: 105059; HomoloGene: 30970; GeneCards: WAS; OMA:WAS - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	48,691,427 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,956,737 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mononuclear cell; ; monocyte; ; blood; ; appendix; ; spleen; ; mucosa of ileum; ; bone marrow cells; ; lymph node; ; trabecular bone;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; thymus; ; spleen; ; mesenteric lymph nodes; ; blood; ; bone marrow; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; GTPase regulator activity; SH3 domain binding; protein binding; identical protein binding; actin binding; protein kinase binding; small GTPase binding; actin filament binding;
Cellular component	cytoplasm; cell-cell junction; vesicle membrane; actin cytoskeleton; extracellular exosome; cytoskeleton; cytosol; actin filament; nucleus; actin cortical patch; site of double-strand break; phagocytic vesicle;
Biological process	defense response; Fc-gamma receptor signaling pathway involved in phagocytosis; actin filament organization; negative regulation of cell motility; blood coagulation; positive regulation of Arp2/3 complex-mediated actin nucleation; actin filament-based movement; endosomal transport; actin filament polymerization; regulation of T cell antigen processing and presentation; immune response; epidermis development; actin polymerization or depolymerization; T cell receptor signaling pathway; T cell activation; regulation of catalytic activity; Rho protein signal transduction; regulation of actin polymerization or depolymerization; regulation of lamellipodium assembly; Cdc42 protein signal transduction; regulation of stress fiber assembly; negative regulation of stress fiber assembly; actin cortical patch assembly; endocytosis; positive regulation of transcription by RNA polymerase II; positive regulation of actin nucleation; actin cortical patch localization; protein-containing complex assembly; cellular response to interferon-gamma; positive regulation of double-strand break repair via homologous recombination; regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	7454
	22376
	ENSG00000015285
	ENSMUSG00000031165
	P42768
	P70315
	NM_000377
	NM_009515
	NP_000368; NP_000368.1
	NP_033541
	Wikidata
View/Edit Human	View/Edit Mouse

The Wiskott–Aldrich syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system that in humans is encoded by the WAS gene. In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to 'open'. This exposes a domain near the WASp C-terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin.

WASp is the founding member of a gene family which also includes the broadly expressed N-WASP (neuronal Wiskott–Aldrich syndrome protein), SCAR/WAVE1, WASH, WHAMM, and JMY. WAML (WASP and MIM like), WAWH (WASP without WH1 domain), and WHIMP (WAVE Homology in Membrane Protrusions) have more recently been discovered.