WDR4

WDR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKK
Identifiers
Aliases	WDR4, TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho
External IDs	OMIM: 605924; MGI: 1889002; HomoloGene: 32422; GeneCards: WDR4; OMA:WDR4 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,879,568 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,738,954 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; mucosa of transverse colon; ; gonad; ; gastrocnemius muscle; ; pancreatic ductal cell; ; testicle; ; stromal cell of endometrium; ; body of pancreas; ; vagina; ; ganglionic eminence;
	Top expressed in
	epiblast; ; yolk sac; ; embryo; ; embryo; ; ventricular zone; ; primitive streak; ; granulocyte; ; lens; ; morula; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA (guanine-N7-)-methyltransferase activity; protein binding;
Cellular component	nucleoplasm; nucleus; cytosol; tRNA methyltransferase complex;
Biological process	RNA (guanine-N7)-methylation; tRNA modification; tRNA processing; tRNA (guanine-N7)-methylation; tRNA methylation;
	Sources:Amigo / QuickGO
Orthologs
	10785
	57773
	ENSG00000160193
	ENSMUSG00000024037
	P57081
	Q9EP82
NM_001260474; NM_001260475; NM_001260476; NM_001260477; NM_018669;
	NM_033661
	NM_021322
NP_001247403; NP_001247404; NP_001247405; NP_001247406; NP_061139;
	NP_387510
	NP_067297
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.