XCL2

XCL2
Identifiers
Aliases	XCL2, SCM-1b, SCM1B, SCYC2, chemokine (C motif) ligand 2, X-C motif chemokine ligand 2
External IDs	OMIM: 604828; MGI: 104593; HomoloGene: 130513; GeneCards: XCL2; OMA:XCL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	168,543,997 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,763,096 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; blood; ; lymph node; ; bone marrow; ; duodenum; ; appendix; ; epithelium of colon; ; placenta; ; right lobe of liver;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; spleen; ; blood; ; choroid plexus of fourth ventricle; ; right kidney; ; secondary oocyte; ; jejunum; ; uterus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; CCR chemokine receptor binding; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; blood circulation; neutrophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; positive regulation of T cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6846
	16963
	ENSG00000143185
	ENSMUSG00000026573
	Q9UBD3
	P47993
	NM_003175
	NM_008510
	NP_003166
	NP_032536
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1. It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. Its gene is located on chromosome 1 in humans.