YAP1

YAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX
Identifiers
Aliases	YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1
External IDs	OMIM: 606608; MGI: 103262; HomoloGene: 4452; GeneCards: YAP1; OMA:YAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,233,424 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,004,597 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; germinal epithelium; ; tail of epididymis; ; urethra; ; seminal vesicula; ; human penis; ; parietal pleura; ; superficial temporal artery; ; pericardium; ; corpus epididymis;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; internal carotid artery; ; primitive streak; ; vestibular membrane of cochlear duct; ; external carotid artery; ; hair follicle; ; retinal pigment epithelium; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription corepressor activity; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; transcription coactivator activity; protein C-terminus binding; proline-rich region binding; transcription factor binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; transcription regulator complex; cytosol; membrane;
Biological process	regulation of transcription, DNA-templated; contact inhibition; transcription, DNA-templated; cellular response to DNA damage stimulus; cellular response to gamma radiation; transcription initiation from RNA polymerase II promoter; cell population proliferation; regulation of neurogenesis; negative regulation of nucleic acid-templated transcription; positive regulation of transcription, DNA-templated; regulation of hematopoietic stem cell differentiation; response to progesterone; positive regulation of intracellular estrogen receptor signaling pathway; progesterone receptor signaling pathway; cell morphogenesis; vasculogenesis; embryonic heart tube morphogenesis; positive regulation of cell population proliferation; regulation of keratinocyte proliferation; keratinocyte differentiation; negative regulation of epithelial cell differentiation; notochord development; somatic stem cell population maintenance; hippo signaling; regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of organ growth; paraxial mesoderm development; lateral mesoderm development; bud elongation involved in lung branching; lung epithelial cell differentiation; regulation of canonical Wnt signaling pathway; cellular response to retinoic acid; regulation of stem cell proliferation; regulation of metanephric nephron tubule epithelial cell differentiation; positive regulation of canonical Wnt signaling pathway; positive regulation of stem cell population maintenance; negative regulation of stem cell differentiation; negative regulation of extrinsic apoptotic signaling pathway; protein-containing complex assembly; tissue homeostasis; heart process; positive regulation of cardiac muscle cell proliferation; cardiac muscle tissue regeneration; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	10413
	22601
	ENSG00000137693
	ENSMUSG00000053110
	P46937
	P46938
NM_001130145; NM_001195044; NM_001195045; NM_001282097; NM_001282098;
	NM_001282099; NM_001282100; NM_001282101; NM_006106
	NM_001171147; NM_009534
NP_001123617; NP_001181973; NP_001181974; NP_001269026; NP_001269027;
	NP_001269028; NP_001269029; NP_001269030; NP_006097
	NP_001164618; NP_033560
	Wikidata
View/Edit Human	View/Edit Mouse

YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases. YAP1 is a potent oncogene, which is amplified in various human cancers.