YWHAG

YWHAG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E
Identifiers
Aliases	YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56
External IDs	OMIM: 605356; MGI: 108109; HomoloGene: 22725; GeneCards: YWHAG; OMA:YWHAG - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,358,991 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,963,470 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; Pons; ; pars compacta; ; Brodmann area 23; ; spinal ganglia; ; superior vestibular nucleus; ; pars reticulata; ; middle temporal gyrus; ; endothelial cell; ; Brodmann area 46;
	Top expressed in
	CA3 field; ; perirhinal cortex; ; entorhinal cortex; ; primary motor cortex; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; anterior amygdaloid area; ; ventral tegmental area; ; subiculum; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	insulin-like growth factor receptor binding; protein domain specific binding; receptor tyrosine kinase binding; protein binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; focal adhesion; myelin sheath; extracellular exosome; cytoplasmic vesicle membrane; mitochondrion; vesicle; synapse; presynapse;
Biological process	regulation of neuron differentiation; protein targeting; negative regulation of protein kinase activity; regulation of synaptic plasticity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of signal transduction; G2/M transition of mitotic cell cycle; cellular response to insulin stimulus; membrane organization; negative regulation of protein serine/threonine kinase activity; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	7532
	22628
	ENSG00000170027
	ENSMUSG00000051391
	P61981
	P61982
	NM_012479
	NM_018871
	NP_036611
	NP_061359
	Wikidata
View/Edit Human	View/Edit Mouse

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.

This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.