ZBTB1

ZBTB1
Identifiers
Aliases	ZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDs	OMIM: 616578; MGI: 2442326; HomoloGene: 8974; GeneCards: ZBTB1; OMA:ZBTB1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,533,690 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,443,724 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; lymph node; ; right uterine tube; ; mononuclear cell; ; monocyte; ; skin of hip; ; cartilage tissue; ; germinal epithelium; ; stromal cell of endometrium;
	Top expressed in
	cumulus cell; ; lacrimal gland; ; hair follicle; ; trigeminal ganglion; ; blood; ; sciatic nerve; ; lymph node; ; conjunctival fornix; ; female urethra; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; metal ion binding; K63-linked polyubiquitin modification-dependent protein binding; protein binding; protein heterodimerization activity; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear body; nucleoplasm; nucleus; nuclear membrane;
Biological process	positive regulation of T cell differentiation; chromatin remodeling; cell differentiation; positive regulation of pro-T cell differentiation; regulation of transcription, DNA-templated; positive regulation of natural killer cell differentiation; T cell differentiation in thymus; thymus development; immune system process; cellular response to UV; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of T cell mediated immunity; translesion synthesis; B cell differentiation; innate immune response; protein homooligomerization; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	22890
	268564
	ENSG00000126804
	ENSMUSG00000033454
	Q9Y2K1
	Q91VL9
	NM_001123329; NM_014950
	NM_178744; NM_001364323
	NP_001116801; NP_055765
	NP_848859; NP_001351252
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.