ZC3HAV1

ZC3HAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X5Y, 4X52
Identifiers
Aliases	ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type containing, antiviral 1
External IDs	OMIM: 607312; MGI: 1926031; HomoloGene: 10585; GeneCards: ZC3HAV1; OMA:ZC3HAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	139,132,122 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	38,331,538 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; endothelial cell; ; visceral pleura; ; blood; ; Epithelium of choroid plexus; ; parietal pleura; ; jejunal mucosa; ; pancreatic ductal cell; ; superficial temporal artery; ; bronchial epithelial cell;
	Top expressed in
	Paneth cell; ; endothelial cell of lymphatic vessel; ; mesenteric lymph nodes; ; blood; ; granulocyte; ; cumulus cell; ; transitional epithelium of urinary bladder; ; spleen; ; hair follicle; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; RNA binding; cadherin binding; NAD+ ADP-ribosyltransferase activity; NAD+ binding; protein ADP-ribosylase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	positive regulation of interferon-alpha production; immune system process; response to virus; positive regulation of mRNA catabolic process; negative regulation of viral genome replication; positive regulation of RIG-I signaling pathway; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; positive regulation of interferon-beta production; protein poly-ADP-ribosylation; protein ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	56829
	78781
	ENSG00000105939
	ENSMUSG00000029826
	Q7Z2W4
	Q3UPF5
	NM_020119; NM_024625; NM_001363491
	NM_028421; NM_028864; NM_001347122
	NP_064504; NP_078901; NP_001350420
	NP_001334051; NP_082697; NP_083140
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger antiviral protein (ZAP) or Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by viruses by targeting viral RNA for degradation, inhibiting its translation as well as affecting programmed viral frameshifting. ZAP targets CpG rich RNA viral sequences. In addition to antiviral activities, ZAP has been reported to inhibit LINE and Alu retrotransposition.

Alternative splicing occurs at this locus and at least four isoform variants have been described with differing anti-viral activities.

While not sharing larger homologous regions, ZAP shares the uncommon CCCH zinc finger motif with tristetraprolin (TTP), which binds AU-rich elements (ARE) in RNA and promotes their degradation.