ACVR1B

ACVR1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H9R, 3MTF, 3OOM, 3Q4U, 4BGG, 4C02, 4DYM
Identifiers
Aliases	ACVR1B, ACTRIB, ACVRLK4, ALK4, SKR2, activin A receptor type 1B
External IDs	OMIM: 601300; MGI: 1338944; HomoloGene: 20906; GeneCards: ACVR1B; OMA:ACVR1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,997,078 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,111,565 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; middle temporal gyrus; ; pancreatic ductal cell; ; renal medulla; ; Brodmann area 23; ; beta cell; ; lateral nuclear group of thalamus; ; parotid gland; ; kidney tubule; ; Brodmann area 10;
	Top expressed in
	transitional epithelium of urinary bladder; ; epithelium of stomach; ; hair follicle; ; skin of external ear; ; olfactory tubercle; ; prefrontal cortex; ; Paneth cell; ; nucleus accumbens; ; ventromedial nucleus; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; growth factor binding; activin binding; metal ion binding; kinase activity; transmembrane receptor protein serine/threonine kinase activity; inhibin binding; protein binding; activin-activated receptor activity; ATP binding; ubiquitin protein ligase binding; protein serine/threonine kinase activity; activin receptor activity, type I; SMAD binding; transforming growth factor beta-activated receptor activity; transforming growth factor beta receptor activity, type I;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; activin receptor complex; cell surface; cytosol;
Biological process	hair follicle development; regulation of transcription, DNA-templated; positive regulation of erythrocyte differentiation; extrinsic apoptotic signaling pathway; phosphorylation; positive regulation of pathway-restricted SMAD protein phosphorylation; in utero embryonic development; negative regulation of gene expression; nodal signaling pathway; positive regulation of trophoblast cell migration; protein phosphorylation; central nervous system development; development of primary female sexual characteristics; positive regulation of gene expression; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of activin receptor signaling pathway; regulation of signal transduction; negative regulation of cell growth; protein autophosphorylation; peptidyl-threonine phosphorylation; signal transduction; positive regulation of transcription by RNA polymerase II; activin receptor signaling pathway; G1/S transition of mitotic cell cycle; transforming growth factor beta receptor signaling pathway; pattern specification process;
	Sources:Amigo / QuickGO
Orthologs
	91
	11479
	ENSG00000135503
	ENSMUSG00000000532
	P36896
	Q61271
	NM_004302; NM_020327; NM_020328
	NM_007395
	NP_004293; NP_064732; NP_064733
	NP_031421
	Wikidata
View/Edit Human	View/Edit Mouse

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.

ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.